Cold agglutinin disease is actually a group of disorders that are characterized by antierythrocyte autoantibodies that bind red blood cells at cold temperatures (< 37° C), causing hemagglutination. Chronic Cold Urticaria is a disease where hives, or large red welts form on the skin. The welts are usually itchy and often the hands and feet will become itchy and swollen as well. Hives vary in size from about the size of a pencil eraser to as big as a quarter or larger.
Children with allergies will often have dark circles under their eyes, called allergic shiners. They might also have a small crease near the bottom of their nose (nasal crease) from pushing their nose up because it is itchy. Inside their nose, the mucosa will often be pale and swollen, while it is usually red and inflamed when you have a cold.
COLD (chronic obstructive lung disease): Any disorder that persistently obstructs bronchial airflow. COLD mainly involves two related diseases — chronic bronchitis and emphysema.
Both bronchitis and emphysema cause chronic obstruction of air flowing through the airways of the lungs. The obstruction is generally permanent and progresses (becomes worse) over time.
Chronic Cough Caused by Postnasal Drip
Postnasal drip is a condition in which mucus drips down the back of the throat causing a cough. This generally occurs because of an overproduction of mucus in the airways. It is common for postnasal drip to be accompanied by a sore throat, and can sometimes lead to an ear infection or sinus infection. Postnasal drip tends to worsen when lying flat because of excessive mucus in the upper respiratory tract. Postnasal drip may be caused by hay fever, allergies, sinusitis, a cold, or the flu.
Less common causes include: congestive heart failure, disorders of the upper airways, disorders of the pericardium, bronchogenic carcinoma, interstitial lung disease, chronic pulmonary infection (e.g., tuberculosis), cystic fibrosis, interstitial lung disease, and psychogenic disorders.
Asthma. This is a common cause of chronic cough in adults and the leading cause in children. Most often, the cough occurs with wheezing and shortness of breath, but in one type of asthma, cough is the only symptom. An asthma-related cough may come and go with the seasons, appear after an upper respiratory tract infection, or become worse when you’re exposed to cold air or certain chemicals or fragrances.
Treatment of Chronic Cold
Some treatment methods for Chronic Cold
Rituximab has been used for the treatment of chronic cold agglutinin disease. This agent is a monoclonal antibody specific for the CD20 antigen found on the surface of B-lymphocytes. Treatment results in B-cell depletion and a potential decrease in production of autoantibodies. The regimen used to treat chronic cold agglutinin disease in several case studies and in 1 small trial was 375 mg/m weekly for 4 doses.
Obviously, the most important thing is to stay warm.
Some air conditioned rooms and pools may be too cold for the skin.
Warming up immediately usually aids in the relief of the itching.
Allergy medications such as Benadryl , Zyrtec , and Allegra may be taken to prevent and get rid of hives.